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084f2db8c6 J. Trace 3 (Physical mixture of Ofloxacin & Lactose ) shows absence of peak at 278.330C and slight pre shift in Lactose peaks. UpdateClose Presentation Statistics loading. Post Reply Close Saving. The position of the material is identified by spraying the plate with certain reagent or exposing the plate to UV Radiation. Send to Blogs and Networks Processing . Excipient : Substances which are included along with drugs being formulated in dosage form, so as it impart specific qualities to them.
Hence they are said to be INCOMPATIBLE Excipient may have Functional group, it reacts with API.NEED FOR DRUG EXCIPIENT COMPATIBILITY STUDIES: NEED FOR DRUG EXCIPIENT COMPATIBILITY STUDIES Stability of the Dosage form can be maximized Avoid surprise problems DECS data is essential for IND Drug discovery can emerge only new chemical entityTYPES OF INCOMPATIBILITY: TYPES OF INCOMPATIBILITY 1.Physical Incompatibility : It involves in the physical form of formulation which involves color, Liquefaction, phase separation or immiscibility. Pharmacy (PHAQA-1/1) (256212885054) Malla Reddy College of Pharmacy Under the Guidance of Mrs . Since the vapor pressure of solution is lower than that of solvent, solvent vapor condenses on solution sample causing its temperature to rise. Comments Posting comment. G. Some excipients have p-Glycoprotein efflux-pump inhibiting properties. So not able to prevent but enhance Hydrate formation of Theophylline. Note: Mixture should be examined under N 2 to eliminate oxidative and pyrrolytic effects at heating rate ( 2, 5 or 10 0 c / min) on DSC apparatus .PowerPoint Presentation: Trace 1 of figure 1-4 shows peak at 278.330C. Highly sensitive method but the cost of carrying out the method & the availability of well established other techniques & methods, this method is generally not preferred .DRUG-EXCIPIENT INTERACTION: DRUG-EXCIPIENT INTERACTION Drug- Excipient Interaction : Excipient can initiate, participate in chemical or physical interactions with drug compound, it alter the effectiveness of a medication.